The Buffalo Bills and the defending Super Bowl champions Los Angeles Rams kick off Week 1 on Thursday night.
On Sunday, there are 14 games highlighted by the Cleveland Browns at the Carolina Panthers, Pittsburgh Steelers at the Cincinnati Bengals, Green Bay Packers visiting the Minnesota Vikings, and the Tampa Bay Buccaneers at the Dallas Cowboys on Sunday night. Week 1 concludes on Monday night with the Denver Broncos at the Seattle Seahawks.
Thursday, September 8th:
| Matchup | Time | TV |
| Buffalo Bills at Los Angeles Rams | 8:20 pm | NBC |
Sunday, September 11th:
| Matchup | Time | TV |
| New Orleans Saints at Atlanta Falcons | 1 pm | FOX |
| Cleveland Browns at Carolina Panthers | 1 pm | CBS |
| San Francisco 49ers at Chicago Bears | 1 pm | FOX |
| Pittsburgh Steelers at Cincinnati Bengals | 1 pm | CBS |
| Philadelphia Eagles at Detroit Lions | 1 pm | FOX |
| Indianapolis Colts at Houston Texans | 1 pm | CBS |
| New England Patriots at Miami Dolphins | 1 pm | CBS |
| Baltimore Ravens at New York Jets | 1 pm | CBS |
| Jacksonville Jaguars at Washington Commanders | 1 pm | FOX |
| New York Giants at Tennessee Titans | 4:25 pm | FOX |
| Kansas City Chiefs at Arizona Cardinals | 4:25 pm | FOX |
| Las Vegas Raiders at Los Angeles Chargers | 4:25 pm | CBS |
| Green Bay Packers at Minnesota Vikings | 4:25 pm | FOX |
| Tampa Bay Buccaneers at Dallas Cowboys | 8:20 pm | NBC |
Monday, September 12th:
| Matchup | Time | TV |
| Denver Broncos at Seattle Seahawks | 8:15 pm | ESPN |
