The Pittsburgh Steelers and Cleveland Browns kick off Week 3 on Thursday night at 8:15 pm on Prime Video. On Sunday, 14 games are on tap, including the Buffalo Bills at the Miami Dolphins, Detroit Lions at Minnesota Vikings, Philadelphia Eagles at Washington Commanders, and the Green Bay Packers at the Tampa Bay Buccaneers.
Week 3 concludes on Monday night with an NFC East matchup between the Dallas Cowboys and the New York Giants at 8:15 pm on ESPN, ABC, and ESPN2.
Thursday, September 22nd:
| Matchup | Time | TV |
| Pittsburgh Steelers at Cleveland Browns | 8:15 pm | Prime Video |
Sunday, September 25th:
| Matchup | Time | TV |
| New Orleans Saints at Carolina Panthers | 1 pm | FOX |
| Houston Texans at Chicago Bears | 1 pm | CBS |
| Kansas City Chiefs at Indianapolis Colts | 1 pm | CBS |
| Buffalo Bills at Miami Dolphins | 1 pm | CBS |
| Detroit Lions at Minnesota Vikings | 1 pm | FOX |
| Baltimore Ravens at New England Patriots | 1 pm | FOX |
| Cincinnati Bengals at New York Jets | 1 pm | CBS |
| Las Vegas Raiders at Tennessee Titans | 1 pm | CBS |
| Philadelphia Eagles at Washington Commanders | 1 pm | FOX |
| Jacksonville Jaguars at Los Angeles Chargers | 4:05 pm | CBS |
| Los Angeles Rams at Arizona Cardinals | 4:25 pm | FOX |
| Atlanta Falcons at Seattle Seahawks | 4:25 pm | FOX |
| Green Bay Packers at Tampa Bay Buccaneers | 4:25 pm | FOX |
| San Francisco 49ers at Denver Broncos | 8:20 pm | NBC |
Monday, September 26th:
| Matchup | Time | TV |
| Dallas Cowboys at New York Giants | 8:15 pm | ESPN |
