Pennsylvania kicks off Week 5 of the college football season at Dartmouth on Friday night at 7 pm on ESPNU. On Saturday, Temple battles Memphis, Villanova at Maine, Delaware hosts Towson, Penn State clashes with Northwestern, Lehigh hosts Monmouth, Rutgers against Ohio State, and Delaware State battles Robert Morris to wrap up Week 5.
Friday, September 30th:
| Matchup | Time | TV |
| Pennsylvania at Dartmouth | 7 pm | ESPNU |
Saturday, October 1st:
| Matchup | Time | TV |
| Temple at Memphis | 12 pm | ESPNU |
| Lehigh vs. Monmouth | 12 pm | ESPN+ |
| Villanova at Maine | 1 pm | FloSports |
| Delaware vs. Towson | 3 pm | FloSports |
| Penn State vs. Northwestern | 3:30 pm | ABC |
| Rutgers at Ohio State | 3:30 pm | BTN |
| Delaware State vs. Robert Morris | 6 pm | ESPN+ |
