The Indianapolis Colts and Denver Broncos kick off week four on Thursday night at 8:15 pm on Amazon Prime Video.
On Sunday morning, the New York Giants and Green Bay Packers are in London for a 9:30 am start on NFL Network. The other games happening on Sunday are the Chicago Bears at the Minnesota Vikings, San Francisco 49ers at the Carolina Panthers, Philadelphia Eagles at the Arizona Cardinals, Dallas Cowboys visit Los Angeles against the Rams, and the Cincinnati Bengals clash with the Baltimore Ravens on Sunday night.
Week 5 closes out on Monday night, with the Las Vegas Raiders visiting the Kansas City Chiefs at 8:15 pm on ESPN.
Thursday, October 6th:
| Matchup | Time | TV |
| Indianapolis Colts at Denver Broncos | 8:15 pm | Prime Video |
Sunday, October 9th:
| Matchup | Time | TV |
| New York Giants at Green Bay Packers | 9:30 am | NFLN |
| Pittsburgh Steelers at Buffalo Bills | 1 pm | CBS |
| Los Angeles Chargers at Cleveland Browns | 1 pm | CBS |
| Houston Texans at Jacksonville Jaguars | 1 pm | CBS |
| Chicago Bears at Minnesota Vikings | 1 pm | FOX |
| Detroit Lions at New England Patriots | 1 pm | FOX |
| Seattle Seahawks at New Orleans Saints | 1 pm | FOX |
| Miami Dolphins at New York Jets | 1 pm | CBS |
| Atlanta Falcons at Tampa Bay Buccaneers | 1 pm | FOX |
| Tennessee Titans at Washington Commanders | 1 pm | CBS |
| San Francisco 49ers at Carolina Panthers | 4:05 pm | CBS |
| Philadelphia Eagles at Arizona Cardinals | 4:25 pm | FOX |
| Dallas Cowboys at Los Angeles Rams | 4:25 pm | FOX |
| Cincinnati Bengals at Baltimore Ravens | 8:20 pm | NBC |
Monday, October 10th:
| Matchup | Time | TV |
| Las Vegas Raiders at Kansas City Chiefs | 8:15 pm | ESPN |
